Showing posts with label SBE. Show all posts
Showing posts with label SBE. Show all posts

Saturday, October 26, 2013

Gladys Hobby : a Calvinist, on a catholic mission...

From September 1940 till December 1943, Dr Gladys Hobby, a devout Presbyterian on a catholic mission ("Penicillin-for-all") , daily visited the Green wards of Columbia-Presbyterian hospital, where the young victims of green SBE waited out their inevitable deaths.

Daily, she held aloft before them a petri dish just aglow with radiated golden penicillium mold, as if it were some marvelous medical monstrance.

As she and her tiny team undoubtedly believed it was.

Monday, October 21, 2013

"Code Slow", the wartime SBE patients and Hearst's "Code Yellow"

What really happens whenever a family directs a hospital that its relative receives the full and rapid CPR response ("Code Blue") in the event of their quickly fatal cardiac or breathing arrest ?

Most the time, the medical and nursing staff will do their damnest to bring that patient back from the imminent grave.

But at times, the medical and nursing staff will form a silent consensus that they will just pretend to "code blue" a patient, but will actually merely go through the motions.

This is known as "Code Slow" and it is a serious breach in medical ethics.

The staff do so because (a) they believe that particular patient isn't worth saving ----(b) or less controversially , they honestly believe that particular patient at this point in their illness can't really be saved by fullout CPR and will merely experience additional pain en route to their death.

Reasons (a) and (b) are often mixed confusingly in actual practise ---- patients judged (subconsciously) as less valuable are more often also judged less able to benefit from full out CPR on strictly medical grounds.

WWII 's own "CODE SLOW"


During WWII, the millions of young people worldwide who had e potential to suffer the invariably fatal disease known as "Subacute Bacterial Endocarditis" (SBE) as a result of endemic Rheumatic Fever, were viewed by both Allied and Axis medical elites alike as 'useless mouths' during a total war.

They consumed a lot of scarce medical care and even if 1% of the time their illness was checked , it always returned a few months later and no one was ever known to survive a second or third hospital stay while suffering SBE.

True, by early 1943, Martin Henry Dawson had cured a few SBE patients , at least the first time, with moderately high amounts of what little public domain penicillin was available between 1940 and 1943 , but the Allied medical elite decided his success had to be discounted at all costs.

For if his success with SBE was accepted and publicised , it would lead overnight to a sudden sharp public demand for enormous amounts of penicillin.

(The thinking being that ordinary doctors would believe that if penicillin can cure SBE, the Mount Everest of infectious disease, then surely to God it could easily cure their patient's less invariably fatal infection.)

This would guy the game for those who hoped to use penicillin as a secret weapon of war - keeping it secret from the Allied public and hence the Axis-friendly diplomatic corps, so it was only available  to the Allied side during the big D-Day push.

It would also guy the game for those who hoped to hold off the public demand for this miracle drug until it had been safely synthesized and patented, when Big Pharma would finally freely sell it to everybody dying of bacterial infections ---- provided the dying or their families also had big wallets.

The hope was to keep Dawson's success out of the public eye until penicillin had been both patented and had been a surprise success on D-Day - mostly by denying him anymore public domain penicillin to repeat his feats.

He was known as not the type to 'spill all' to the press if he was denied more penicillin.

The SBEs wouldn't be denied all medical care and simply left to die, tempting as that was, because that could backfire and clash fearsomely with the Allied talk of the Four Freedoms.

Instead, they would be "code slow"-ed to death : given enormous amounts of useless (and abundant) sulfa drugs so their families would think something useful was being done for them, when it actually was not.

Unfortunately for these schemers, a fiery Italian American doctor,Dante Colitti, armed with his own private grudge against a medical elite for being prejudiced against allowing Italian Catholic cripples to get medical licenses, was far more willing to go to the media.

He got the master of the Yellow Press, Citizen Hearst and his paper chain, to go full out on behalf of this miraculous Yellow Magic stuff.

The rest, as they say, is history.

For in the end, "Code Slow" proved no match against "Code Yellow" .

A "Good News Story" from the "Bad News War".....

Thursday, September 26, 2013

ALL life is worthy of life as a full citizen or are just SOME judged 'worthy' ?

Nazi Germany - even at the depths of its imminent defeat - treated its full citizens well : recall that POW Kurt Vonnegut was working in a Dresden factory that made food supplements for pregnant mothers at the time of that city's Allied firebombing in February 1945.

But its non full citizens it killed outright or worked to death as starved slaves.

'Life worthy of Life' - 'Life unworthy of Life' are infamous German cum Nazi catchphrases that have come to symbolize THEM, so as to separate US for any shared responsibility for the horrors of  the
eugenic mass murder of WWII.

But when we re-cast those catchphrases as' life worthy or unworthy of life as full citizens' , we become uneasily aware that no society in the early 1940s was free of the sin of treating some of its members as less than fully human.

None .

When Henry Dawson proved this up for the Anglo Allies over their denying of life saving penicillin to young SBE patients deemed useless for the war effort - judged just 'useless mouths' consuming valuable medical resources - he made it clear to many just how close the Nazis and their erstwhile opponents really were, morally......

Saturday, September 21, 2013

Dying life unworthy of wartime penicillin was Life unworthy of Life

"all Life is worthy of Penicillin"


The infamous term "Life unworthy of Life", created by a German psychiatrist Alfred Hoche in the 1920s , is generally thought of as bring used exclusively by the Nazis.

Used by them during a Total War to justify killing everyone from working class Aryan babies with developmental issues to the entire Jewish population of Europe.

But the term had a much greater transnational appeal than that .

Prominent American psychiatrist Foster Kennedy thought , in 1941 and 1942, during that same Total War, that the USA would be justified in killing its little Aryan babies with developmental issues.

Shamefully, America's leading psychiatric journal actually agreed with him and only one psychiatrist disputed his thesis.

And the Allies' medical establishment, led by Dr Chester Keefer and his NAS committee, used this idea to justify denying SBE-curing penicillin to young people dying of SBE all over the Allied world,  because they felt that even a cured SBE patient was still useless to the Total War effort.

("Life judged unworthy of Penicillin.")

By contrast, Henry Dawson and a handful of other doctors worldwide supported, and fought for, the notion that "All Life is worthy of Penicillin" - even in , particularly in , a Total War supposedly  fought precisely against the evil idea that some Life was, ipso facto, unworthy of Life.....

Thursday, September 19, 2013

WWII was a conflict within nations and within INDIVIDUALS ... as well as between nations

War ,to give it a quick definition, is a violent conflict conducted between nations, not between individuals.

But the intensity of commitment with which individuals and groups within any nation fight in that nation's war can vary immensely --- perhaps never more so than during WWII.

(We are not considering the rare case when a citizen is in total non-compliance with their nation's war decisions, by becoming a complete conscientious objector or a traitor.)

The existing WWI paradigm ,within which all existing history on that war has been written to date , never denies that each nation had a somewhat divided mind between 1931-1945 on various war issues.

Still writers accepting of that paradigm tend to focus exclusively on the nation against nation conflict and - I claim ! - seriously distort what was really going on and what was truly fundamental in a 'long history' view.

These writings tend to limit the war's big moments to a military battle between the modern age's various ideologies : liberal capitalist democracies versus race (Japan, Germany,and Italy's fascism) and class based (communist Russia) dictatorships.

There is no denying that for the world's population living inside the modern age bubble seventy five years ago , it was the differences between the various strands of modern thought that so dominated their minds.

But what excuse have we historical-minded authors , living seventy years after that bubble began breaking, to be 'captured' by our protagonists' ways of thinking ?

Historians like to claim lots of time is necessary between historian and event to render the beginnings of an objective assessment of it.

Isn't seventy five years (and more) time enough to look anew at WWII ?

To see it no merely as a Modern war, but in fact the last Modern war, and the beginnings of the post-Modern world ?

If we look again at the three big Modern ideologies : liberal capitalist imperialism, fascist cum racial imperialism and communist imperialism, we could today try to see that what they had in common , as opposed to what divided them.

What they held in common was an exclusivist or imperialist worldview that divided all the world into those deserving and those undeserving of the basic rights of humanness.

Does it really matter now, except in the details, whether or not their 'undeserving' included blacks or Jews or well off peasants ?

A Leningrad communist harshly criticizing another young communist for sharing her ration with her dying grandmother, saying the grandmother can contribute nothing to the struggle against the Nazi siege, but that young girl could and she needed all that food to keep up her strength.

A Nazi plan to kill off all German mentally challenged children in taxpayer-supported institutions so that their hospitals and staff could be used instead to look after moderately wounded soldiers capable of returning to the front.

An Allied medical establishment ( take your pick : America, the UK , Canada or Australia ) callously saying SBE was not 'a war disease' and so wives dying from it must be denied life-saying penicillin, so erring husbands with VD can return to fight on the front-lines.

This modern age utilitarianism and instrumentalism run wild - can you really tell its practitioners apart,  without a label ?

But there was an individual-based counter-reaction against it.

People all over the world between 1931 and 1946 began to internally wrestle with the morality of a exclusivist versus inclusivist worldview.

Admittedly tiny in numbers at first when it came to open rebellion against the Modern worldview, this critique came to centre on the idea that wartime penicillin should be offered to all and any.

We do know it received widespread public support, from August 1943 onwards,  at a time when the polls said that most peoples' hearts were still hardened against treating the Jew or black as fully human .

SBE, a rheumatic heart disease, was primarily a poor person's disease : the people who got it tended to be the poor among the visible minorities and immigrants.

The world's daily press correctly sensed it first.

They sensed the widespread public support for the idea these young patients with SBE should be saved, war or no war ---- number one by making a lot lot lot more penicillin than had been produced during the 15 years to date.

By 1949, the once-radical change was complete and modern exclusivity was being replaced plank by plank by our current post-Modern inclusivity.

So, for example, the  idea that it was right that enemy children should die because members of the Allied population had cut their penicillin for illicit gain was now widely viewed by film-goers as the ultimate of all possible evils,  as indicated by the viewer love of  a film that still ranks in the top ten of all time : "The Third Man" .

If only Henry Dawson was still around in 1949, to see what change in the public morality that he had wrought ....

Saturday, September 14, 2013

WWII: Bullies and Bystanders vs Innocents and Intervenors

NYC-based Dr Henry Dawson in 1941 was clearly an intervenor with his 'inclusive' penicillin (and may I point out that adult intervenors (as I well know) were often bullied themselves as children).

 SBE patients , such as his patients Charlie and Miss H were clearly the innocents.

NYC-based Dr Foster Kennedy in 1941 was clearly a bully, particularly telling that he would use the excuse of the shortage of staff and resources during an upcoming war as an excuse to finally implement his long held plan to kill all the deformed children.

Shades of Adolf Hitler in an exactly similar setting.

His active verbal supporters at the very top of the world's largest and most influential mental health body, the American Psychiatric Association, were clearly the stone-hearted bystanders a bully needed to get away with his deeds.

In the wider world of WWII, one can easily spot the bullies, the innocents and stone hearted bystanders (aka Neutrals)  as individuals and as (almost) entire nations.

But sadly, no one nation stands out as a whole hearted intervenor.

That noble task is left to a few in all nations, to try and heal the hearts of the stone-hearted majority by rousing their consciences  to the sad and unfair fate of the small and the weak in face of bullies.

Bullies like Hitler, Stalin, Tojo and sometimes even people like Churchill and others on the Allied and Neutral side.....

Friday, September 13, 2013

So I am a punster , is that such a crime !?

Stone-heartedness : physical or moral affliction or both ?


I am sure a gene is responsible.... or its early neural damage while a child-to-be is still resting on the placenta.

Whatever.

Punning can't be cured - only endured.

So my 'stone-hearted' : a play on the stone-like calcined formations on the heart valves that defines the SBE disease that Henry Dawson eventual cured with his 'inclusive' penicillin ?

Did Dawson merely want to see these teenagers and youth enjoy all the courting and dancing that all the others their age enjoyed : 'dancing' over stone (hearted valves) ?

Did he merely hate to think of the SBEs slowly dying inside mentally and emotionally as well as physically, as their medical condition forbade them doing anything vigorous and youth-like , in case it hastened their inevitable early end ?

Or is my title a broad hint that Dawson's real target was much bigger than the few dozen lives he saved directly : was his inclusive penicillin really aimed at curing all of the morally stone-hearted ?

That is to say, the majority of us between 1931 and 1945.

The us who were so determinately indifferent to doing anything concrete to save our weaker and smaller neighbours when they were under attack by big bullies like Hitler , Stalin and Tojo ?

The same morally stone-hearted of us who refused to allow any live-saving penicillin go to the physically stone-hearted SBEs ?

Or all of the above .......?

Wednesday, August 21, 2013

War medicine was from Mars, Social medicine from Venus ?

The very word "war" medicine seems to stir something vaguely Mars-like, deep within the soul of the chickenhawk doctor or scientist.

Successfully conceiving ,in an academic lab at the University of  Chicago, a way to reduce combat deaths from shock seems to transport one almost up to the frontline evacuation hospitals, directly under hostile fire.

Being there, doing it, roughing it , all sweaty and virile-like : medical science with the smell of the locker room and the men's shower stall about it.

By contrast, what can any doctor - any real doctor - actually do about those dying of subacute bacterial endocarditis (SBE) ?

These hopeless cases shouldn't even be occupying an acute hospital bed - particularly in wartime.

They should be handled by women - nurses - in a secondary hospice or in a palliative care situation at home.

And arthritis 'care' - not really medicine is it ? Helping impoverished old ladies too frail to bend over properly to get dressed and to do their toiletry.

Again - women's work. A job for personal care assistants and social work case workers. Social medicine.

But (Martin) Henry Dawson persevered , hung on in there , all through the war, treating those chronically ill with arthritis and the very 4Fs of the 4Fs, those dying of SBE .

Perhaps because he was that rarity : an American medical researcher in 1940 who already had a stirling war record in the front lines (in the medical corp, infantry and artillery), with a medal for valour and two serious war wounds to back him up.

The Military Cross winner from Venus, as it were ......

Tuesday, August 20, 2013

Henry Dawson, Champion of the Second Chance ... and the Second Glance

Manhattan-based doctor (Martin) Henry Dawson championed the smallest, weakest and poorest of beings all his life.

On one hand, they were human beings, such as the institutionalized chronically ill at Goldwater Hospital.

Or discarded young people , dying needlessly from subacute bacterial endocarditis (SBE).

In both cases, he wanted to give them a second chance at a near normal life in what was, after all, the famed City of the Second Chance.

On the other hand, sometimes his focus was upon microbe beings, creatures about whom it can't really be said that he wanted to ensure their continued survival - he felt they did that well enough on their own !

Instead, he merely wanted all of us to take a Second Glance at just how well these incredibly tiny ,delicate, immobile sacs of water managed against extremities of physical conditions and the potent threat of the human immune system and modern medicine.

Starting in the 1920s, he pioneered studies of their survival techniques such as HGT, Quorum Sensing, Molecular Mimicry and Biofilms : still cutting edge science even today, eighty years later.

His subtle point was that if these, the smallest of the small, can manage survival so well than perhaps small human beings and small human nations can also manage equally well, if we just let them live rather than trying to enslave and kill them in the name of  a Progress that must always be Bigger , to be Better.

The Allied governments  never one to miss a chance to match the Axis in moral turpitude , wanted wartime penicillin to remain a secret available only for the 1As - "Penicillin from New York's Cold Spring Harbour's Eugenics lab" , as it were.

The tired, poor huddled 4Fs


Dawson was equally bull-headed in wanting to see the Nazis combatted morally as well as militarily, by demonstrating just how well we looked after our tired poor and huddled 4Fs,  even during a Total War : "Penicillin from New York's Emma Lazarus", as it were.

Janus-like Manhattan tried both approaches at first ,  very  strongly favouring the eugenic approach, until a few good Manhattanites rose up in protest.

Then wartime Manhattan was revealed to also come from the Venus of love and peace as well as from the Mars of anger and war.

Finally ... a Good News Story from the Bad News War.

Sunday, August 4, 2013

It's Milton's AGAPE not the Greek AGAPE...

I have been going backwards and forwards in my mind - and in my heart - about the exact spelling (and pronunciation)  of my book title.
Agape with a macron (a long flat line as a accent) over the "e" at the end of the word signals the Greek word and meaning : pronounced a-GAP-eh, all slurred together.

 A word, used mostly by Christians, to mean an openness to others' needs.

Agape, without the macron, is a word invented by the famous Christian poet John Milton, from the word "gape" : to stare, open- mouthed.

A + gape gave us "agape", to be in the state of open-mouth-ness, in wonder,awe and eagerness.

Pronounced :  (soft a)  A   gape , with a small separation between A and gape.

As I have said in previous blogs, Dr Francis Peabody said that  a-GAP-eh ,to be truly effective in helping someone in need , requires our mind as well as our heart.

We must care about an individual, in all their unique individuality, if we are to be effective in caring for that individual's needs.

Dr Henry Dawson had spent a dozen years, from 1927 to 1939,  listening - really listening - to the strivings of Life's smallest and weakest beings, the microbes.

 So he was in an excellent position, starting in September 1940, to effectively care for some of the wartime world's smallest and weakest human beings.

 They were "the 4Fs of the 4Fs" , the many young SBE patients dying needlessly of wartime benign neglect, by direct orders from the top of the Allied medical-scientific establishment.

His heart was open (agape) to the needs of the SBEs, but so were the hearts of many other doctors before him.

But unlike them, his mind was also open (agape) to the solution : medicine made by foul-smelling microbe feces , aka natural penicillin.

So Milton's Agape fits Dawson's efforts more completely than does the Greek Agape' from the New Testament, which also fits, but only partially so.

Similarly, my book's sub-title could refer the Gospel message (Good News).

Or it could merely repeat a cliche from contemporary news-reporting : with newscasters always trying to finish off the mostly grim news of the broadcast by ending with a "brite" or a "Good News Story" : a lighter toned, uplifting story.

One immediately thinks of the Anne Murray song, "A Little Good News", written by Rocco, Black and Bourke.

Its arresting opening referenced "Bryan Gumbel talkin' about the fightin' in Lebanon" --- a totally unexpected something cum hook  I am sure immediately caught the ear of every songwriter on the planet.

My book's title and sub-title doesn't preclude someone thinking of them as terms from the New Testament of two thousand years ago ,  but I wish to say that for me at least,  it is a variant of that old eternal message, but dressed in current post-modern garb....

Wednesday, July 31, 2013

A Presbyterian with a Monstrance of Penicillium Mold

Devout Presbyterian layperson and wartime penicillin researcher Gladys Hobby recounts in her book "Penicillin : Meeting The Challenge" of  her rounds carrying a petri dish containing a big circular 'wedged' penicillium mold, every day through the wards at Presbyterian-Columbia Hospital.

This daily pilgrimage served no medical or scientific purpose, but it did serve the moral purpose of helping to sustain the spirits of the young SBE patients there.

They all knew that faced imminent and inevitable death from their disease, unless the tiny team of which she was a part of could produce in time enough of the natural penicillin to save their lives.

Anyone who has even seen an artistic rendering of  such 'wedged' penicillium mold and an artistic rendering of a Monstrance is immediately struck, as I was, that the two paintings are very hard to tell apart.

As a Catholic, I particularly relish the image of a Calvinist Protestant dutifully carrying a monstrance, so alien to her religious traditions ( and albeit a monstrance of penicillin-hope), daily through the pain-filled wards.

Truly, God works in mysterious ways ....

Sunday, July 28, 2013

Francis W Peabody : agape starts in the mind and moves to the heart

In the mid-1920s a busy dean of medicine, among many other things, briefly addressed a student body.

And then a year or two later he died, the early victim of fatal sarcoma.

Normally a dean of medicine from 80 years ago is remembered, if at all, only as one name among many underneath the long lines of dusty portraits in the hallway leading up to the office of the current med school dean.

But in fact Francis W Peabody lives on, bigger than he ever was in real life, because of a very short phrase he spoke to that student assembly, just one of the many things he did in the course of a short but very busy, productive life.

Fame into Posterity, indeed, is ever a case of quality over quantity.

In his talk, Peabody suggested a re-boot of the traditional common sense definition of charity and agape altruism : it was not enough to be 'open' to the needs of someone in pain or trouble --- to be agape with your heart.

It isn't even likely to be medically effective.

One , first, needs to be agape with your mind  : to be open to others' activities, to them as individuals, individuals with an inherent dignity , even when not needy.

"Caring for an individual really begins when we first care about them as individuals," said Peabody.

He emphasized that the main satisfaction in the medicine life is through the forming of brief but intimate bounds with patients and their families, even if the medical staffer fails to obtain a medical cure.

Dawson and Peabody, not Dawson and Cole ?


Now it is well known that Dr (Martin) Henry Dawson was a 1926-1927 NRC Fellow at the Rockefeller Hospital in New York, becoming the first to ever work with DNA in a test tube, before moving on to Columbia Presbyterian Hospital and his equally pioneering work with Penicillin.

But his arrival at Rockefeller was not his only choice - dare I suggest, perhaps not his first choice as a NRC fellow ?

The journal SCIENCE records in May 21 1926, that Dawson could take his fellowship at Rockefeller under Dr Rufus Cole or at Boston's Thorndyke Lab under Dr Francis W Peabody.

But, alas, Peabody already had terminal sarcoma and so was too ill to take on new fellows - he died later in 1927.

It seems like a tragically missed opportunity, because I see very little of Cole in Dawson's character while he and Peabody could have been soul brothers.

In October 1940, for the first time in his medical career, Dawson's heart was fully open (agape) to helping save the lives of the many young people facing certain death from the dreaded SBE, subacute bacterial endocarditis.

(SBE was in a section of medicine about as far from his medical day job as a disease could be, so he won't have normally had an opportunity to exercise whatever agape his heart might have felt for the SBE patients.)

And his was hardly the only heart open to helping the SBEs, the "4Fs of the 4Fs".

(Admittedly , when he did get involved, he went much further than anyone else to save them in wartime when the Allied governments had collectively ordered that they to be abandoned to a certain death.)

But Dawson's mind was also agape, that rare scientist in 1940 who was truly open to taking in all that that life's small and the weak were capable of, whether in need or not.

So as a result, he was intellectually ready to understood what the other doctors and the rest of humanity circa 1940 could not, that a lowly fungi mold (among the "4Fs" of non-human life) could indeed be capable of saving the SBE and many others as well, when the best of human chemists had repeatedly failed.

His intellectual agape made his emotional agape medically effective.

Dawson's intellectual courage in seeing natural penicillin could cure the SBEs and then having the emotional courage to continue to apply that cure, against stiff wartime Allied government opposition, is the best example we have of Francis Peabody's dictate in action...

Thursday, July 25, 2013

Aktion 4F : something done to 4Fs, rather than something done for 4Fs ?

For years, I have thought and written of Dr Henry Dawson's efforts to try and save the lives of young SBE patients ,"The 4Fs of the 4Fs" , as if it was a sort of counterpoint to Nazi Germany's efforts to kill similar chronically ill people, the infamous Aktion T4 campaign.

His own Aktion 4F as a sort of counterblast to their Aktion T4.

But Dawson wasn't actually directly opposing the German Nazis' murderously utilitarian disposal of humans judged useless consumers of badly needed resources in a Total War.

He was combating similar notions held by the powerful in the Anglo-American medical establishment.

The OSRD , the NAS and the MRC all judged SBE to be a "militarily unimportant disease" and refused to allow any penicillin be diverted to saving its patients.

This despite Dawson demonstrating over and over that penicillin was the only thing that could cure this hitherto invariably fatal disease dubbed "the Polio of the Poor".

So in a way, the Allied treatment of the SBE 4Fs , along with their diverting penicillin away from badly wounded frontline troops in the Mediterranean towards otherwise fit soldiers who had deliberately contracted VD to avoid combat , could be see as exact counterparts to how the Nazis behaved in similar medical situations.

(For example, secretly killing Eastern Front soldiers rendered permanently mentally ill in combat to free up medical beds and supplies for soldiers judged able to return to battle eventually.)

In which case, the co-ordinated campaign , around the Allied world , from the US to Canada to Britain to Australia , to deny penicillin to SBE cases, can be seen as being the true Aktion 4F.

Food for thought....

Tuesday, April 30, 2013

Allies gave penicillin only to 1A soldiers for same reason they gave Czechoslovakia only to Hitler

The Allies weaponizing penicillin was as morally wrong as appeasing Hitler by giving him Czechoslovakia on a platter , and for exactly the same reasons.

The Allies totally failed to see that giving everything to the mighty and nothing to the weak was exactly what caused the war in the first place: weaponizing penicillin was not going to win the war but rather cause Allies to lose the moral peace.

'Eugenicide with an English accent' was not a moral counterweight to Hitler's values, but merely an Anglo-Saxon cousin of his.

Henry Dawson realized, very early on in the Fall of 1940, that any cause willing to save the lives of its very weakest, such as the SBEs, even during a Total War, would be a cause worthy of dying for.

By contrast, any cause that was only a weak 'me too' of its enemy's morality wasn't going to get 20 year old infantrymen up and out of their foxholes with any alacrity when the whistle blew.

Justice is only truly just when it is as fair to the weak as it is to the mighty, as fair to the foolish as it is to the wise : but God knows it isn't easy to make each new generation of humanity realize this.

The Germans, Japanese, Soviets did have a cause they believed was worthy of dying for, perverted as it was ---- one reason why as individuals and in small groups, they were usually much better troops than any of their opposing Allied troops.

Interestingly, the free Polish troops were also considered to be braver than the other Allied troops : they knew they were going to have to fight very hard to secure the postwar fate of Poland - to keep it out of Allied Russian as well as Axis German hands.

They lost, thanks to FDR - but Dawson didn't.

Penicillin was de-weaponized , albeit only by loud public demand and against government wishes,  and the Allies narrowly escaped being accused, postwar, having having caused a war crime of omission....

Tuesday, April 23, 2013

1939-1945 : Nesvizh Jews fight for life, at home and abroad

While Jews in the democratic West during WWII were unwilling  to do something even as minor as chaining themselves to government fences ( a la the suffragettes) to protest the mass killing of their counterparts in Europe, this did not mean that other Jews were not fighting for their right to life in those years.

Consider the brave Jews of Nesvizh.

Ninety percent of the Jews of that small city, 60 miles south west of Minsk (today part of Belarus, then part of Poland), were killed by the Germans, in one day, in October 1941.

The remaining 600, locked in a tiny ghetto, resolved to try an armed breakout, rather than die quietly.

The forests were right next to the city and the ghetto and once the Jews were in the woods, filled with lethal partisans hidden behind dark trees, the Germans and their helpers quickly lost their dutch courage and gave up the chase.

On July 21 1942, hearing a police company of Nazi collaborators was coming to kill the remaining 600, the Jews started their break out.

Yes, most got killed in the process, but perhaps 10% of the 10% got away to try and survive the grim and short lives of forest partisans.

Maybe a handful of the original 6000 survived to the end of the war.

Nevertheless, this tiny ghetto was the first, or one of the very first, groups of Eastern European Jews to fight to the death in an effort to stay alive.... and is widely honored worldwide today for doing so.

Particularly by those children of Western Jews who know their own parents and grandparents, under far more safe circumstances, did basically nothing, certainly nothing so bold and courageous, during WWI to hinder the Nazi efforts to kill all of the world's Jews.

Most of the Jewish people of  Nesvizh survive today as the children, grandchildren and great grandchildren of the people of that shtetl who emigrated to places like New York in the brief window of opportunity between the 1890s and the start of WWI.

Charlie Aronson 


We still know very little about this man, the very first person to receive lifesaving penicillin-the-antibiotic (systemic penicillin) and who did so on October 16 1940 in New York.

We do know a fair bit of his medical history, but as to Charles Aronson himself, we only know he was born about 1913.

We are very lucky that in 1944 much of his complicated medical history was abstracted by his doctor in a published article because today's America would let us know nothing of this man born a 100 years ago.

America is a country where it is much easier to buy an assault rifle then it is for a historian to get any personal information about historical figures.

But importantly we do know a fair bit of the career of his doctor (Dr Henry Dawson) , particularly with regard to the disease that Charlie Aronson was being treated for (subacute bacterial endocarditis) (SBE).

Prior to Charlie, Dawson had never treated SBE and obviously , at that point, no one had treated anyone anywhere with systemic penicillin.

From these few scant facts, we can make a few educated , aka statistical, guesses about the identity of Charlie.

Because some academics have studied the matter thoroughly, we have a pretty good idea of how ordinary (non well-to-do) New Yorkers picked the solutions to their medical problems in 1940.

The densely populated centre of New York City is also home to one of the world's largest arrays of hospitals and doctors in the world.

A short bus ride in any direction in the three mile circle around your home threw up lots of possible healers.

Even the poorest weren't short of choices - many NYC hospitals and doctors were also research oriented and if you submitted to their new therapy trials, you got (hopefully) cutting edge treatment for little or no cost.

Generally, distance was a big factor : since so many good hospitals lay close at hand in every direction, so why go further only to find your family and friends can't easily visit you daily ?

The exception was if a doctor or hospital was very famous for its special advanced treatment of a particular fatal disease : then people would come from all over the continent or the world, desperate for a possible lifeline.

Dr Henry Dawson ,and systemic penicillin, in October 1940, were the furthest possible from that sort of fame in the case of SBE.

In October 1940, nobody had a cure for SBE : when you got very sick with it, you went to any old hospital and patiently waited to die from this 99% invariable fatal disease.

So in looking for a patient named Charles Aronson, born around 1913, who attended Columbia Presbyterian Hospital in upper Manhattan in October 1940, the first place to look is in the recent release of the 1940 federal US census, seeking a man of that name and age living pretty close to the hospital.

As it happens, the only man having that name and age in the 1940 census living within a few miles of Columbia- Presbyterian lived very close indeed: two miles away at 1202 Vyse Avenue in the (South) Bronx.

(The handwritten census indication of the street is often misread as Nyse Avenue (sic!).

Most - but not all - of the people in New York City in 1940 named Aronson were recent Jewish immigrant families from The Pale of Russia , places like today's Poland, Ukraine and Belarus.

Places like Nesvizh.

The Charles Aronson born around 1913 living at 1202 Vyse Avenue, has a brother Samuel, a sister Lillian, a mother Olga and a father Alex.

Vyse Avenue, in 1940, was home to a closely knit community from the Minsk and Nesvizh areas and so when we see an Alex Aronson from the Bronx on two lists of members of a Nesvizh landsmanshaften, we may well have something.

(Landsmanshafts were Jewish fraternal organizations based on all members being former residents of a very small part of the Old World. Think of it as a big neighbourhood emigrating en masse and re-constituting itself in another country. It functioned as a hometown collective self-help, burial and social organization.)

The 1940 census says that Alex and Olga were born in the former Russian Empire in the late 1880s (and Minsk/Nesvizh was certainly part of that Empire back then.)

Charlie and his siblings were all born in New York and I feel we can safely speculate that Olga and Alex migrated to New York as twenty year olds just before WWI and started their family there.

The 1940 census tells us not just ages and birthplaces and current residence, it tells us of the education, occupations and incomes of all on the census.

Luckily the youngest Aronson of this family , Samuel, was asked a few more questions - in particular he said his childhood home language was Jewish (Yiddish), indicating this family was in fact Jewish.

Alex had 3 years of school, worked as a machine operator making ladies cloaks, earning $1400 a year ( a typical skilled working class wage in that year.) Olga had no formal education and worked at home as a homemaker.

Samuel had one year of college and was looking for work as a machine operator making ladies belts.

Lillian had 4 years of High School and made $900 a year as a machine operator making ladies belts.

Charles also had 4 years of High School and was making $950 a year working as a teletype operator at a newspaper.

Perhaps at a gentile newspaper but far more likely at a Jewish newspaper.

If this Charles Aronson was the same one who received history's first ever shot of antibiotic and went on to recover from invariable fatal SBE not just once but twice, it was remarkable he had so much education and had a skilled job.

Because the SBE Charlie had had many close calls with death and permanent disability.

When he was eight,in the early 1920s, Charlie had gotten Rheumatic Fever (RF) , which until 1960, the leading case of death in school age children.

His was an unusually severe version, as it hit the cells of his joints, the cells of his heart and the cells of his nerves.

He was lucky not to die - most poor kids at that time did die outright from this severe an attack.

Then he went right on to get a severe attack of the post WWI worldwide epidemic of a mysterious sleeping sickness, encephalitis lethargica, not at all to be confused with the disease caused by the tropical tsetse fly.

Today the evidence points away from what was originally seen as the cause, flu, and towards an auto immune response to particular strains of strep bacteria causing a case of strep throat weeks or months before the onset of this particular disease.

Rheumatic Fever is another in a whole series of auto-immune diseases caused by some people's particular gene set over-reacting to certain strains of strep throat bacteria.

Thanks to Oliver Sacks, most people today know far more about sleeping sickness than do they of Rheumatic Fever, and most know that while many died of the initial attack, others survived it only to become victims of permanent post-infection parkinsonism.

Such was SBE Charlie's unlucky fate.

Still he survived two should-be fatal attacks by strep before 1940 and remarkably he would survive two more should-be fatal attacks by different strep bacteria between 1940 and 1944.

And a life-threatening stroke : a cat of more than just nine lives !

These latter strep were the normally harmless mouth strep bacteria than can invade damaged heart valves caused by Rheumatic Fever and almost always (before systemic penicillin) kill the patient : the dreaded SBE.

Attacks to your nerve cells  such as hit Charlie twice, can give a person temporary or semi-permanent mental, emotional and behavioral issues.

The Nazis in particular feared those with this form of sleeping sickness and their Aktion T4  murder teams usually sought out and killed such people, even when the person generally functioned as a hard working tax paying citizen.

Such as poor Martin Bader, who was murdered by German doctors in late June 1940.

This was the very same time as two American doctors, Dawson along with Dr Karl Meyer, were first learning of penicillin's unknown systemic potential from unpublished verbal reports from an American student forced to leave Oxford University after the Fall of France.

Already the two were thinking of it for a new use as a life-saving therapy.

Dawson was a humanitarian doctor but in addition his particular private research interest was oral strep diseases.

Charlie may have been a last minute attention to the initial SBE penicillin trial (despite Dawson not having enough penicillin for one, let alone two SBE patients) because he had survived both RF and sleeping sickness and now was under attack from strep bacteria for a third time.

Charlie never faced direct assault from Nazis as did his remaining relatives in Nesvizh, if that is where indeed his dad came from.

But Charlie's life was threatened by Nazi-like thinking by the American medical elite, who felt, like Himmler and Hitler, that SBE patients, particularly if they also suffering from parkinsonism, were just useless mouths to feed in an all-out total war, and so should be left to die---- in this case, by deliberate neglect.

They ordered doctors not to waste penicillin on SBE patients.

Charlie and Doctor Dawson fought back - not with guns - but Dawson did break the wartime laws and did steal scarce government controlled penicillin, all to keep SBE patients alive.

His "ACTING UP" finally provoked a national and then international public reaction against the Allies' Nazi-like attitude to SBE patients and penicillin.

The character of Allied penicillin also changed at that moment - from a secret weapon of war, to a public and universal life-saver.

Dawson himself was dying of an auto-immune disease from 1940-1945 and did not live to see the end of the Nazis, but Charlie did.

To the Polish government at the beginning of the war, Charlie was a Polish citizen living overseas.

No country in the world had a worse war than the Poland of the 1939 boundaries.

The Allies with great consistency treated it as badly in 1945 as they did in 1939, matching the Nazis stroke for stroke.

It is satisfying to know that at least one citizen of Poland was treated fairly during WWII, treated as fairly as every individual should be treated all the time,  and that the result of his being treated with compassion, penicillin became about the only good news story that ever did come out of that bad news war ....

Monday, March 25, 2013

1940 Penicillin : localized Gas Gangrene or systemic SBE ?

Within days of reading war-dodger Howard Florey's published conclusion that the as-yet-unproven penicillin was particularly suited to the military's most feared infection, gas gangrene, war-hero Henry Dawson defiantly decided - by pointed contrast - that penicillin was particularly well suited to defeat the ultimate in non-military infections, deadly subacute bacterial endocarditis, SBE.

The timing of Dawson's decision - during the most critical days of the expected Invasion of Britain - only heighten this highly unusual contrast between how we expect war-heroes and war-dodgers to behave and how these two examples actually did behave.

Florey had declined to serve his country when he was young but now was very eager to aid it (as a draft-proof middle ager) by steering the new penicillin towards use as as a local antiseptic for gas gangrene infections in frontline casualty tents.

For centuries, gas gangrene infections were the most dreaded and also the most uniquely wartime forms of death (rarely causing death in peacetime).

Any talk of the possibility of finally ending gas gangrene's terrors was acutely pitched to catch the ears of war's political, military and medical leadership.

By contrast, when on the day of America's first peacetime Draft Registration, a day dedicated to locating all of America's 1A youth,  Dawson choose to instead try and save the lives of two SBE sufferers, one Black and one Jewish, he was focused on the most 4F imaginable of the unwanted 4Fs.

The most 4F of all the 4Fs : the SBEs


For no nation's military , no matter how hard pressed for manpower, was likely to regard SBEs as more than just a particularly costly burden for a wartime economy to bear.

It usually hit young adults , the prime category for draft boards and munition factories, but no matter what modern medicine threw at it, it always ended after months of expensive effort with the inevitable death of the patient.

In that Fall of 1940, the Medical School at Columbia University, which employed Dawson, had moved to reduce its offerings in Social medicine and up its offerings in War medicine, in response to the battle for civilization not taking place over the skies of Britain.

It certainly had no cause to expect any complaints from professor Dawson, he of all its employees.

He was, after all, from a Canadian family of five brothers, all who volunteered to fight in WWI, all who were wounded in the front lines - one who had paid the ultimate price and others who got medals for bravery and leadership under fire.

Dawson likely had more front line experience - in the medical corp, the infantry and in artillery - than any one else in the Medical School.

When he wasn't serving in hospitals dealing with wounded soldiers, he was in military hospitals himself as a patient - fighting off life-threatening infected war wounds he himself received.

Surely such a patriot and such a veteran of battlefront infections  saw the sense on Howard Florey's proposal to focus penicillin research on battlefront wound infections  and to agree with his university's decision to focus on war related medical research ?

But clearly he did not - and the mystery is to account for why he did not - but instead, precisely and perversely, did exactly the opposite.

Penicillin did not, in the end, reduce deaths due to gas gangrene - in fact penicillin pioneer ( and WWI veteran) RJV Pulvertaft found that the evidence suggested that the percentage of gas gangrene sufferers who died actually went up in WWII , compared to the results obtained in the last years of the previous war !

By contrast, in the end, penicillin proved to be the best medicine ever seen to stop deadly systemic (body-wide) infections like SBE and blood-poisoning.

Explaining the mystery and the paradox


Based on just the evidence, part of the mystery might therefore seemed to solve itself: the modest Dawson was simply a far better scientist than the very pushy and ambitious, but ultimately plodding, Florey.

But Dawson was also extremely patriotic in ways that Florey couldn't begin to imagine and we still must explain why he felt  that his best way to personally aid the war effort was to come to the aid of Life's weakest members.

Saint Peter had only denied Christ's pleas three times, but between 1931 and 1941, America had denied pleas for help from smaller, weaker countries under attack over two dozen times, only deciding
to put the Greatest Generation Ever to work fighting the only Good War, after it itself was attacked.

Helping Life's weakest members is all very nice in theory said America - but what in the hell does it have to do with fighting WWII - which was all about one's own naked self interest ?

Perhaps Dawson was merely confused -  was still fighting WWI - was still fighting for poor bleeding little Belgium.

Perhaps....

Tuesday, February 19, 2013

Resetting the Allied moral compass so that it diverged from the Nazis, not merely followed a muted parallel course

It remains unknown whether Henry Dawson expected his quixotic wartime efforts (to "waste" weaponized penicillin on 'useless' SBEs ) to go as far as they ultimately did.

He certainly was extremely unhappy that America was treating its wartime 'SBE lives unworthy of life' in almost as bad a fashion as Nazi Germany was known to be doing to its SBEs and others seen as "useless mouths".

But did he suspect his assault on weaponizing penicillin would extend beyond the Allies' horrific wartime neglect of the poorer chronically ill ?

He probably couldn't have foreseen just how quickly the pipeline of ever-newer ever-better sulfa drugs would dry up or just how quickly so many strains of deadly bacteria would become resistant to any sulfa drug , leaving penicillin as the  only  wartime lifesaver between disease and death.

This meant de-weaponizing penicillin had consequences far beyond those people suffering from SBE and denied their only chance at life.

If weaponized penicillin had remained throughout the war successfully censored and had remained denied to the civilian world (as weaponized DDT successfully was, never let us forget) , it would have ranked as one of WWII's major war crimes, like Katyn Forest or Auschwitz.

Millions of people around the world during WWII would have died needlessly from massive infections that only penicillin alone could have stopped.

Penicillin in 1943 was not as it is today,  just one among dozens of antibiotics - it was the only one - and in addition, no new anti-bacterial sulfa drugs were coming along to replace the ones that bacteria had so rapidly grown resistant to.

Refusing to divert a tiny amount of war resources to make penicillin available to civilians - anywhere and everywhere - was to refuse them Life itself.

Worse, there was no trade-off  to debate ; penicillin, like sulfa before it, was no war-winning secret medical weapon, at least in its intended war-winning use at the front .

Brand new (front line) wounds either contain abundant alternative bacteria foods to the deadly sulfa 'food' (the Fildes theory, known since 1940) or contain abundant proteins to bind to penicillin and render it useless.

However penicillin, and sulfa, were very useful a little further back in the military hospital system, as a life-saving systemic in cases of possible blood poisoning.

The case against secret weaponized penicillin gets even worse.

As an impure natural drug, penicillin would have taken the Germans at least a year or two or three to successfully mass produce it , even if its virtues had been sung from the heavens by the American media in 1942.

But as a pure synthetic penicillin in supposedly cheap abundant mass production (an event that in fact as not yet ever occurred) the chemistry-minded Germans would have rapidly back-engineered the drug and synthesized it rapidly themselves.

Because remember it took 15 years of hard effort to purify natural penicillin enough to determine its structure - but only months thereafter to 'synthesize' it artificially.

Back-engineering that synthesis would also only have taken months.

Penicillin's real secret was just how difficult the mass production of natural penicillin could be if you set your mind on doing everything the hard way ---- not the OSRD-Merck-Oxford fantasy of secret synthesis.

Dawson certainly set up the stage for the Allies re-setting of their moral compass , from his endocarditis efforts from September 1940 to September 1943 : but it was the immediate outcry resulting from the Patty Malone and Marie Barker cases that forced them to actually do something concrete.

His gut instinct in 1940 ,that not treating the otherwise fatal subacute bacterial endocarditis would prove the acid test for the Allies' pernicious morality, certainly was correct.

But while he couldn't have foreseen how far his actions would impact, he wouldn't have been unhappy that they did so......

The Cure for Auschwitz Disease : "Dawson's Crude" : .56% penicillin ...and 99 and 44/100ths pure love

Pray there comes a day when most premature deaths really are 'Acts of God', when even the best of money and the best of medical care could not result in a happy ending.

But until that happier day, most premature deaths in the world - in peace as in war - are 'Acts of Humanity' , or rather 'Acts of Lack of Humanity'.

Sins of Omission : premature death caused because the people dying are not judged (by others more fortunate) as worthy of devoting much money or effort towards saving.

In war, comparatively few people die as soldiers dying of mortal wounds gained in combat.

The Nazis' behavior provides a particularly clear example of this.

They fed and cared for  the captured POWs and enemy civilians of some nations (the Dutch for example) but for other (Russians and Poles for example) many or most of these people were shot after battle or left to starve and die of disease from lack of food, medical care and shelter.

The food and fuel saved as a result meant that no German citizen went hungry or cold.

The right kind of German civilian anyway.

Using the war as excuse, the Nazis killed many German civilians, those judged 'life unworthy of life' , to free up food and hospitals for other Germans.

In another well known example of  WWII's Sins of Omission, Winston Churchill ignored the pleas of his top British officials in India and let four million poor Bengali civilians needlessly starve to death in 1943-1944 ,rather than divert some food and some shipping from  Allied peoples he judged more worthy of receiving them.

Even the different death rates from wounds gained in combat  , among the so called "modern" nations engaged in World War Two is revealing.

The Americans and British generally devoted more resources to saving their wounded compared to the Germans, Japanese, Russians and Italians.

 As a result,more western Allied troops survived the same severity of wound as experienced by troops of these other nations.

'Of course', I hear you say, 'they were richer nations, it was easy for them !'

But no : they had a choice, because the extra money devoted to this extraordinary care of the wounded could have been allocated elsewhere: to more and better anti-tank artillery, for example.

An extraordinary effort to produce the best anti-tank artillery ever made was , in fact, probably the cheapest way for the Western Allies to have ended the war against Germany at least a year earlier than it did, saving millions of lives all around.

I raise the genuine issue of better earlier anti-tank artillery versus the best possible military health care to remind us that even total war still leaves us with genuine moral choices.

More Lancaster bombers versus more 17 pounder anti-tank guns versus raising everyone's morale by generously providing penicillin enough for all people were some of the choices - part political, part moral, part economical - that leaders had to make in WWII.

Making the wrong ones meant the war dragged on longer than it had to, costing more lives lost.

It is not enough to say Churchill won the war in 1945 ; better to ask, could he have won the war in 1943 ?

In 1940, Henry Dawson was battling a near universal mindset among the world's research-oriented doctors of that time : that a medical researcher's only task was to determine that disease A was caused by bug B and that bug B was killed by compound C.

Then, like sleeping under a bridge, the researchers considered that the cure for disease A was open to rich and poor alike : pay for three weeks of needles at $10 a shot: together with doctors fees, say $250 in total.

When the annual wages of the working poor, if they found work, was very lucky to be $750 in 1940, that was a cure well beyond their reach.

Besides the fact that their disease might be far harder to cure than that of someone well off, due to the cumulative affect of their lack of good nutritious food for years and years.

Or that fact that living, as they did, in poor and crowded housing, disease A was more likely to come back again, even after an impossibly expensive cure.

Now what if disease A is something one gets from having open wounds - such as the open wounds all civilian mothers have after childbirth, or the open wounds that soldiers get after exposure to shell fire in battle.

How do we judge western Allied governments unwilling to provide the only life saver for disease A , either to any civilian moms (except those personally known to lead disease A researchers) or to any soldiers with wounds so severe they will be discharged and pensioned off, if they live ?

And how do we judge these governments when at the same time, they are gladly willing to provide live-saving compound C  (totally free !) to men who had either very high and very low peacetime incomes, just as long as their war wounds (by sheer luck) are only moderately severe and they can be expected to return soon to combat duty ?

Is this attitude not different in kind from that of the Nazis, but merely different in degree ?

Dawson had no realistic expectations that a few small injections of a very crude penicillin powder, hastily made in a few weeks, would cure such an incurable invariably fatal disease as subacute bacterial endocarditis, (SBE), then as now the acid test of all infectious diseases.

His powder had only about 8 to 9 units of penicillin per mg in it ; ie it was only about .56% pure.

The rest (the remaining 99 and 44/100ths worth),was in many researchers' minds, "junk".

Rather as they later described most of our DNA : "junk".

I believe Dawson considered his little bit of brown powder to be .56% penicillin and 99.44% pure love.

99.44% pure care, concern, caring.

For Dawson was judging his attempt to save Aaron Alston and Charlie Aronson by a much different - and much more moral - acid test.

To Dawson, SBE in the Fall of 1940 was not the acid test of infectious disease, but rather the acid test of pernicious morality.

These SBE patients were be judged to be 1940 America's "4Fs of the 4Fs", suffering from the militarily most useless disease on earth and not worthy of wasting any precious medical resources upon.

Now a doctor named Francis Peabody that Dawson had hoped to train with (but who died of cancer before that could occur) had earlier and famously said that the care of the patient begins (only begins in fact ) if the doctor first cares about the patient.

A single doctor can't hope to directly save everyone dying in a big war.

But by setting a very public example about caring for the least of these, those judged "unworthy of life", even in the midst of a war , they can hope to begin to still the trigger fingers of those all too willing to kill prisoners  just because 'it is too much bother to bring them back to our own lines'.

Only when the world is willing to care about "useless" others, even in the midst of wars, can we expect to begin to see war deaths reduced to combat mortal wounds, and then to ultimately see lesser and shorter and less brutal wars.

Only in a world where ordinary people care about others judged "useless", can we expect to still the hand that dropped the pellets at Auschwitz .

Which is why I earnestly claim that Dawson's Crude was the best and only cure for the Auschwitz Disease ....

Friday, February 8, 2013

Re-setting the Allies' moral compass : the acid test of penicillin for wartime endocarditis

Please correct me : but in all my research I could find no indication that in his 15 years of medical research before October 16th 1940, (and he was a world-class expert in the area of strep bacteria) Henry Dawson had never written or spoken one peep - not one peep - on the subject of endocarditis, a very common and deadly disease, usually caused then by a variant of strep bacteria.

Dawson was a scientist who spoke and wrote a lot , so his silence , until October 16th 1940, was surely hardly from lack of opportunity.

Nor was it bureaucratically and professionally easy, in October 1940 anymore than it would be today, to go from being the director of an outpatients' clinic on chronic arthritis to suddenly becoming the lead doctor on a totally new treatment of such an acute cardiac illness as subacute bacterial endocarditis (SBE).

At least not in a big teaching hospital, with all boundary-conscious specialists rigidly defined in each area.

So we are still left with the puzzle explaining why Dawson literally gave his life to suddenly treat and cure this hitherto incurable disease, endocarditis.

It helps to recall that as a paid up member on the side of Social medicine at a time when War medicine was in the ascendancy in the corridors of Columbia Presbyterian Medical Centre that Fall, Dawson's ears must have zeroed in on the disease quickly voted "the absolutely lowest priority disease in all War medicine" : and that SBE.

The overall consensus that that the SBEs consumed endless amounts of medical care, generally only to quickly die anyway.

Or if they did by some weird chance recover - this time - they couldn't much useful war work with their weakened heart and anyway would surely succumb to a second bout of SBE.

Dawson might even have agreed with this assessment , albeit reluctantly, before October 1940 : nothing, not even the much vaunted brand new sulfa drugs, did anything to extend the SBEs' chances.

But to Dawson, if not to any one else in the world,  the written claims about this new , as yet untested, drug penicillin seemed to offer a way out.

It promised activity against SBE's green strep bacteria, good diffusibility and above all , near absolute non-toxicity.

The latter was critical because ("Blood, blood everywhere and not a drop to drink") ironically the heart's values have almost no internal blood supply and must be 'dabbed' by a drug filling the entire blood supply, as it whistles past the heart valves at break neck speed.

An internal "antiseptic" as it were.

Any drug strong enough to instantly push its way through the thick vegetation on the heart valves and quickly kill the strep within , as it rushed on by at 'breaking the speed limit speeds' was also strong enough to be toxic to the entire human body.

SBE was a "disease designed by a committee" : a committee of Devils creating a disease so devilish as to even frustrate God Himself.

SBE seemed an impossible cure -- surely a quick death following upon benign neglect was the most merciful choice ?

But none of the SBE experts seemed to feel as he felt ; none was willing to do the sort of heroic medicine required to at least give crude penicillin and SBE  the old school try.

Did Dawson begin to feel that this indifference to the possibility of curing SBE, "the polio of the poor", was just an excuse?

Did he not buy the claim that the difficulties of preparing penicillin together with all the preparations for war medicine and  for prioritizing medicine for the 1A fit  was the real reason for inactivity on SBE ?

Or was it really just an excuse to roll back New Deal efforts to do something medically for the poorest and weakest (the 4Fs) among us ?

Were there not strong rumours about that the Nazis were also abandoning the poorest and the weakest among the German patients, also using the necessities of war to justify their actions ?

Whatever ethical speculation led him to his decision, it is a fact that on October 16th 1940, Henry Dawson made the wartime treatment of the weakest of the weak, the 4Fs of the 4Fs, the ultimate acid test for the moral compass of the Allied cause.

It took him years - and cost him his life - but he got that moral compass set right, right in the middle of a bloody war.

Finally, treating the SBEs, the least of these, as we would want ourselves to be treated, became the practise of the Allies, not just another plank in their hollow public rhetoric....

Sunday, January 13, 2013

Most of the penicillin grown in its first 15 years, was wasted on useless attempts at synthesis, not used to save the dying

If my claim be wrong : show me the money !

Open all the archives on university, hospital and corporate penicillin files.

Show us the size and number of penicillin production runs, month by month, from September 1928 to September 1943 ( ie including the first four years of the war).

Then shows us the amount of penicillin units actually released for therapeutic use on human patients suffering from infections suspected of  being defeatable by penicillin,  during that same time period.

Patents, Profits and Patriotism : pick two out of the three...


I have never seen any published accounts where the responsible authorities complained about all the precious potentially life-saving penicillin that was being wasted ---- during an all-out Total War ! ----on a futile 20 year long effort to synthesize patentable profitable penicillin from PD (public domain) natural penicillin.

But there are plenty of complaints from the higher-ups about all the penicillin being wasted on saving the lives of ("useless feeders") young people dying from hitherto invariably fatal SBE  (endocarditis)......