Thursday, October 24, 2013

Economics as if human survival really matters

Unbridled growth, even at the cost of burning to death in our own carbon wastes.

This is what the mantra of "ever bigger is ever better" is leading us to.

What it is not leading to is ever greater happiness.

For if the richest and most powerful among us are not happy, who on earth can be ?

Some apparently.

They live and work in smaller walkable communities without - thanks to the likes of Skype and the internet - feeling at all cut off from the great wide world and distant friends and kin.

They use less carbon energy than you or I not because they restrain themselves like monks but because their life is set up spatially to use and need less carbon energy.

They don't miss what they don't need.

More green energy is not the solution to our carbon addiction : more, more, more is never much of a permanent solution - in tumour growth or in real world economics.

We must develop full happy lifestyles where we need less energy to be well off and happy.

Many small communities in the past developed some of the ways to do so ---- often centuries and millenniums ago.

But before Internet and telegraphs and radio , it came at the price of emotional isolation.

Marry the new Internet and those centuries old ways of living compactly and what will be actually born will be hard to predict - but I feel at least confident that it can't be any worse than the route-to-hell we are now taking ....


Penicillin is not Avastin, but it could have been...

My book - The smallest Manhattan Project  - is about us , all 10 billion of us , here today or years dead, whose lives have been improved by the advent of inexpensive penicillin.

In a sense, this book is a rarity : one written from the patient's eye view of how that drug came to be ; a welcome change after decades of endless books exclusively devoted to how penicillin looked to the people who discovered and developed it.

Penicillin is frequently called the Miracle Drug but few consider that its biggest medical miracle was really in fact its cost, or rather 'lack of cost'.

Because the diseases that penicillin treats are contagious,  patients too poor to afford a cure remains a reservoir of the most virulent strains, waiting to infect the rest of us.

There actually were methods of preventing much of these diseases before the development of penicillin : they included the ready availability of good jobs, good food, cleaner and bigger homes, greater social respect.

Baring that, only the worldwide availability of a drug that would cure those diseases once they started up, at a price that almost all could readily afford , could reduce these diseases from being endemic or epidemic to just names in a dusty medical textbook.

That is why I can say, with absolute assurance, that even those of us who have never had a single treatment of beta-lactam (penicillin family) antibiotics are in better health today because the grandparent of them all, Penicillin G , is water cheap - literally a lifesaver "too cheap to meter" .

But it almost didn't happen , we almost lost "inexpensive penicillin".

We almost got an expensively patented synthetic drug more akin to Avastin and all those other $100,000 a year plus medications.

"The smallest Manhattan Project" is the story of a doctor ( himself slowly dying of another unrelated disease) who sacrificed his own health to see penicillin from the patient's point of view.

His name should be honoured for all time.

This, despite the fact that he did not discover penicillin and then neglect it (Fleming) nor did he start its re-discovery and eventual development, albeit while pursuing a pathway that nearly killed off that development (Florey).

Dr Martin Henry Dawson, for that was his name, merely said penicillin should be made available - now! - for every single patient whose life could be saved by it , even during the height of a Total War .

Nay, he went much, much further.

Dawson in fact said all should have access to life-saving penicillin, particularly in the middle of a Total War.

That was because that war was supposedly being fought against one opponent in particular, solely because that opponent's core philosophy said that 'some lives are more worthy than others'.

How could we continue to conduct that war with any moral vigour when our own medical establishment was 'me-tooing' Hitler's doctors ?

Now the mantra 'Penicillin for all who needed it regardless of their income level or skin colour' in the mid-1940s meant its mass production, given the vast amount of infectious disease endemic in those years.

And mass production has its myriad ways of driving production costs down, down , down --- as happily happened in the case of Penicillin G in almost textbook manner.

'Penicillin for all' quickly became 'inexpensive penicillin for all' and once that happened, penicillin began to work almost like the way a good public health vaccine program should work : the treatment of the many ultimately offering 'herd protection' to all the rest of us, free of charge.

Insulin is another drug frequently called a miracle drug.

But the sad fact is that it is far more common today than it was beforeinsulin was discovered, for a variety of reasons.

By contrast, the names of all those bacterial household scourges that so terrified our mothers and grandmothers are not even known to most of us under the age of 50, and most doctors practising today have never seen a case of them.

And that is just the sort of modern day miracle that Dawson's mantra of 'penicillin for all' can produce.

For the complex truth is that our choice of medical ethics has economic consequences and these in turn feedback and have medical consequences.

The case of what the mantra of 'penicillin for all' ultimately led to should be taught in every health economics and health ethics oriented university department for just those very reasons....

Tuesday, October 22, 2013

The light of the littlest red lighthouse can light up the world better than that of the greatest grey bridge

I wonder if Marjorie and Henry Dawson ever read the tale of The Little Red Lighthouse to their youngest child before Henry died in mid-1945 ?

That small and seemingly powerless-feeling child, born in 1941, was of the right age to especially appreciate the special message of the classic children's book, which first came out in 1942.

Particularly considering his father worked daily right beside the real life great grey bridge and the real life little red lighthouse.

If not, I hope the Dawson child eventually absorbed the lesson of that little book more directly, by learning more of his late father's own little Manhattan Project between 1940 and 1945.

Both the example of the book's story and the story of Henry Dawson's tiny Manhattan Project demonstrate to small children the reminder that a determined few, no matter how small in number or in power, can light up the whole world for the better .

And that little children shouldn't give up either, at the first hurdle...

Lifesaving 'too cheap to meter:' the legacy of the smallest Manhattan Project

Remember that solemn pledge from the biggest Manhattan Project ?

After killing a few hundred thousand civilians overseas, they promised to make up for it by offering us endless, abundant, safe electricity at prices 'too cheap to meter'.

They were joking, right ?!

By contrast, consider the legacy of the smallest Manhattan Project.

It has offered us decades of lifesaving at prices 'too cheap to meter'.

That is an amazing feat considering it was performed against the combined resistance from the biggest of the wartime Allied  governments and from many politically powerful firms in wartime's Big Pharma.

Penicillin, more than 85 years after its initial discovery, still can stop cold the toughest bacterial infections going, and do so at prices dirt cheap, offering us true life saving at prices too cheap to meter.

Contrast that to today's to cancer drugs,  averaging at costs between $100,000 to $350,000 a year, that can only promise to extent the average life by about four months.

This is because natural penicillin was born in the public domain, born the original genetic drug , and Man failed totally to synthesize it and expensively patent it.

Penicillin is often called the miracle drug and perhaps its biggest miracle was economic, not medical : it could be given the opportunity to save hundreds of millions worldwide because it wasn't priced like Avastin but rather was almost as cheap as water.

(A real miracle - and I repeat, it almost didn't happen, we almost lost inexpensive penicillin.)

That was because our busy wartime Allied bureaucrats and busy wartime drug executives spent zillions in scarce tax dollars to try to synthesize and patent penicillin rather than getting down to doing Job One with readily available natural penicillin.

Their Job One and Two and Three should have been saving lives in a worldwide war crisis.

Henry Dawson's 'Penicillin-for-all' did not just mean making it available to all at a steep price, like Avastin : it meant making it available to all patients, at a price even the poorest can afford...



Monday, October 21, 2013

"Code Slow", the wartime SBE patients and Hearst's "Code Yellow"

What really happens whenever a family directs a hospital that its relative receives the full and rapid CPR response ("Code Blue") in the event of their quickly fatal cardiac or breathing arrest ?

Most the time, the medical and nursing staff will do their damnest to bring that patient back from the imminent grave.

But at times, the medical and nursing staff will form a silent consensus that they will just pretend to "code blue" a patient, but will actually merely go through the motions.

This is known as "Code Slow" and it is a serious breach in medical ethics.

The staff do so because (a) they believe that particular patient isn't worth saving ----(b) or less controversially , they honestly believe that particular patient at this point in their illness can't really be saved by fullout CPR and will merely experience additional pain en route to their death.

Reasons (a) and (b) are often mixed confusingly in actual practise ---- patients judged (subconsciously) as less valuable are more often also judged less able to benefit from full out CPR on strictly medical grounds.

WWII 's own "CODE SLOW"


During WWII, the millions of young people worldwide who had e potential to suffer the invariably fatal disease known as "Subacute Bacterial Endocarditis" (SBE) as a result of endemic Rheumatic Fever, were viewed by both Allied and Axis medical elites alike as 'useless mouths' during a total war.

They consumed a lot of scarce medical care and even if 1% of the time their illness was checked , it always returned a few months later and no one was ever known to survive a second or third hospital stay while suffering SBE.

True, by early 1943, Martin Henry Dawson had cured a few SBE patients , at least the first time, with moderately high amounts of what little public domain penicillin was available between 1940 and 1943 , but the Allied medical elite decided his success had to be discounted at all costs.

For if his success with SBE was accepted and publicised , it would lead overnight to a sudden sharp public demand for enormous amounts of penicillin.

(The thinking being that ordinary doctors would believe that if penicillin can cure SBE, the Mount Everest of infectious disease, then surely to God it could easily cure their patient's less invariably fatal infection.)

This would guy the game for those who hoped to use penicillin as a secret weapon of war - keeping it secret from the Allied public and hence the Axis-friendly diplomatic corps, so it was only available  to the Allied side during the big D-Day push.

It would also guy the game for those who hoped to hold off the public demand for this miracle drug until it had been safely synthesized and patented, when Big Pharma would finally freely sell it to everybody dying of bacterial infections ---- provided the dying or their families also had big wallets.

The hope was to keep Dawson's success out of the public eye until penicillin had been both patented and had been a surprise success on D-Day - mostly by denying him anymore public domain penicillin to repeat his feats.

He was known as not the type to 'spill all' to the press if he was denied more penicillin.

The SBEs wouldn't be denied all medical care and simply left to die, tempting as that was, because that could backfire and clash fearsomely with the Allied talk of the Four Freedoms.

Instead, they would be "code slow"-ed to death : given enormous amounts of useless (and abundant) sulfa drugs so their families would think something useful was being done for them, when it actually was not.

Unfortunately for these schemers, a fiery Italian American doctor,Dante Colitti, armed with his own private grudge against a medical elite for being prejudiced against allowing Italian Catholic cripples to get medical licenses, was far more willing to go to the media.

He got the master of the Yellow Press, Citizen Hearst and his paper chain, to go full out on behalf of this miraculous Yellow Magic stuff.

The rest, as they say, is history.

For in the end, "Code Slow" proved no match against "Code Yellow" .

A "Good News Story" from the "Bad News War".....

Sunday, October 20, 2013

Birth of Modernity ?

Modernity was born the moment most of the educated West replaced a belief in the Theory of the Sublime with a belief in the Theory of the Germ , ie an event that occurred in the broadly defined '1880s'.


The Theory of the Sublime explains why humans fear - and should fear - only the awesomely big : God, the devil, earthquakes, volcanoes, hurricanes, lions, tigers, et al.

But after the advent of Darwin, Lyell, steam power, high explosives and the Higher Criticism, who could fear any of these ?

Still, when things go wrong - as they often do - who then to blame ?

Can't blame ourselves, could we ?

Conveniently, a bizarre theory emerged from Pasteur in France about the same time, suggesting that an invisible Fifth Column of tiny, weak creatures, most even incapable of basic movement , could nevertheless fell the biggest and smartest of beings with ease.

Think of Germs being a sort of Anti-Sublimity and you're on the right track.

No longer were our enemies big, external and highly visible, (first declaring war forthrightly, then pouring over the border to line up en masse in their bright red uniforms on a sunny daytime battlefield).

Instead germs , like biological franc-tireurs, shot their toxin bullets, - in our backs - at night, out of uniform, from behind fences.

Bacteria are nothing but tiny, weak, poor beings you sentimentalists say ?

No, no, a thousand times no !

They are unsporting guerillas and biological bomb-throwing anarchist terrorists.

War without mercy then upon our minorities of the weak and the small - for they are humanity's one true remaining enemy .....

Modern Era/Modernity: Matter/Anti-Matter

You have to admire the sheer audacity of Modernity as it sought a full compass rollback of the effects of the Modern Era, under the sheep's skin guise of daring to lead this counter-revolution under the name of Modernity !

Albeit it was a subconscious counter-revolution ---- all of its varied proponents went to their graves convinced they were furthering the pace of the Modern Era and merely working to destroy some of its dangerous foes.


So some of the Modern Era's most dangerous foes (and also its biggest supporters) were socialism, liberalism, communism, capitalism, fascism, democracy, totalitarianism.

Like some hair-brained firing squad, the entire world armed itself with intellectual rifles and formed a circle, with each ideology convinced that its opponent directly across the way was Modernity's worse enemy and the erstwhile 'friends' on either side of themselves were only a little bit better.

The Modern Era was notable for many things but it is possible to see that above all else was was truly new about it was the extreme mobility it brought to so many hitherto local human activities.

The increased reach, speed and universality of the flow in and out of local areas (and of entire sovereign nations) of capital, materials, products, patents, intellectual ideas, fashions and tastes, immigrants and warfare was extremely upsetting to most everybody at some time or other.

Reality now seemed seemed so complex, so diverse, so unpredictable, so rapidly changing as beyond human comprehension, let alone human control.

Modernity can thus be best seen as an intellectual claim that - contrary to this current false human sense about reality - a scientific study of Nature actually revealed that real reality was essentially simple, predictable and static, in uniformitarian equilibrium, and any change in it was so gradual as to appear invisible over the average human lifetime.

The Modern Era and Modernity were not one and the same train or even two trains running on parallel tracks, but two trains heading for a head-on wreck on the same track : WWI and WWII ....