Showing posts with label mycologists. Show all posts
Showing posts with label mycologists. Show all posts

Monday, January 14, 2013

A forgotten meme from "The Golden Age of Mysteries" held sway over wartime penicillin : to the detriment of the dying

The grey-haired teenagers of the 1870s to 1890s, the guys who actually ran World War Two, grew up on the stories of the Golden Age of Mysteries and Detectives, starting with Sherlock Holmes' Study in Scarlet in 1887.

And one thing you quickly learned in all those thousands of books in dozens of languages was that the formula that the spy had stolen from the safe - the formula upon which the fate of the Empire ( or perhaps even the world) hung - was never a formula in physics or biology or geology or astronomy.

It was always a formula in Chemistry : always a formula for the synthesis of some extremely powerful explosive or fuel or drug.

Chemistry and synthesis in those days held all the non-chemists in shock and awe --- from at least the1870s until after Hiroshima in 1945.

Much as physics held the minds of non-physicists between 1945 and 1985 and the way micro-biology still holds our non-biologist brain cells.

(Ever since the day we-the-laity first discovered that courts could convict serial murders just on the scientific basis of their trace DNA left at the scene of the crimes.)

The solution for almost every problem that wartime penicillin faced - and there were many - was "throw more chemists at the problem".

The solution for the shortage of penicillin being produced  just had to be "synthesis it - we humans have to be way smarter than mold slime could ever hope to be".

The real solution  - when it came - was surprisingly mundane : like farmers have done for thousands of years, we simply went out and looked for better breeders - in this case, better breeders who gave us, not more milk , but more penicillin instead.

The solution was not a chemical formula from the collective brains of thousands of top chemists, but rather the eyes of one, rather ordinary, mycologist in a fruit market in Illinois.

Remember the black humour vogue for "thin books" ?

(The best known was "Italian War Heroes" - unfair because even the Germans and British felt that the Italians were frequently brave and often very effective.)

the ultimate "THIN BOOK"


A better, truly thin, book would be "Mycologist War Heroes" .

Exactly where were those bastards between 1928 and 1945 anyway ?

They mightn't have been asked, very often, to paid work on penicillin - but they didn't seem to be exactly eager to volunteer either : and the importance of penicillin during WWII  (aside from its chemistry aspects from 1943 to 1945) was hardly top secret .

I suspect most mycologists spent the 'ultimate war between good and evil' either stamp collecting or devising secret ways to use funguses to destroy enemy food crops, aka germ or biological warfare.

Then civilians deaths could be got in truly wholesale amounts - not merely in the paltry retail numbers that Bomber Harris's aerial bombing had produced.

If wartime mycologists had gotten their wicked way, fungi would have still done their part to help win the war.

But not by saving millions, but rather by killing millions.......

Thursday, August 12, 2010

"Jabbing" BIG PHARMA awake

Good things happen when you quit the shilly-shalling and "do the clinical" - ie 'stick the needle in and see what happens'.

I have said before that it was in October 1940 - the same month that Martin Henry Dawson jabbed the very first needle of antibiotics in a patient - that the American Drug Companies and the American medico-scientific establishment (NAS-NRC) finally woke up and started smelling the coffee on penicillin.

Example ?

That very month, Squibb asked for a sample of Fleming's penicillin mold from the culture collection in Peoria.

They did the smartest thing that Squibb ever did in the entire Penicillin Saga - they threw the chemists out of the building and let the mycologists get down and into it.

Don't you wish all the other labs had done ditto?

 Alexander Fleming, unfortunately, seemed to really hate mycologists - and he rarely - in public anyway - disliked anyone

Thankfully, the result was a much improved strain from Fleming's original and it was eventually called NRRL 1249. (January 1942)

All praise to Dr Geoffrey Rake and his co-workers at Squibb who never get any thanks for giving us life-saving penicillin in time for D-Day.

Instead the big losers in the penicillin affair, the chemists, have written all the official histories, blowing smoke rings so we won't see how they failed to deliver on their promises.

Other claims to the contrary,history is usually written by the losers - at least "the losers with l'argent..." *

Mycologists take a bow : thanks to you , it was natural NRRL 1249 and its offspring , 1249.B21, (December 1942) that delivered most of the penicillin produced in World War II.

The chemists just delivered papers and articles instead....

* Canadian-anglophone-only joke --- Yanks and Brits/Anzacs etc can safely ignore it